Immune System may aggravate cancer
Source: Science Daily
Researchers at the Unviverstiy of California have found out that the leukocytes which are part of the innate immune system may be triggered to boost cell growth, remodel tissues whcih are necessary for cancer growth.
The leukocytes have receptors on the surface that can detect foreign antigens. Once a foreign antigen is encountered, it is engulfed and destroyed. But now, the researchers have found out that in the presence of cancerous tissues, the receptors on the leukocytes are misdirected to do a different funcion - boost cell growth and remodel tissues thatare necessary for cancer growth.
The exact signals that make the leukocytes to take this pathway is not yet known but they feel that it may be bacause of the antibodies produced by the B cells since part of the receptor for the antibody known as immunoglobulin appears to be involved.
The good news however is that drugs for treating cancer aggravated by inflammation are already in the trials. So once the exact signals are found out, the work could be completed faster.
The research work was done using mice in which HPV was inserted. It a well known fact that HPV is tumourigenic virus causing cervical cancer. In the experiment, two batch of mice were created. One batch had the antibody receptors intact while the other mice were 'knock-out' of that receptor. The research showed that the former showed rapid growth of cancer cells while the other didn't show much progress.
Researchers at the Unviverstiy of California have found out that the leukocytes which are part of the innate immune system may be triggered to boost cell growth, remodel tissues whcih are necessary for cancer growth.
The leukocytes have receptors on the surface that can detect foreign antigens. Once a foreign antigen is encountered, it is engulfed and destroyed. But now, the researchers have found out that in the presence of cancerous tissues, the receptors on the leukocytes are misdirected to do a different funcion - boost cell growth and remodel tissues thatare necessary for cancer growth.
The exact signals that make the leukocytes to take this pathway is not yet known but they feel that it may be bacause of the antibodies produced by the B cells since part of the receptor for the antibody known as immunoglobulin appears to be involved.
The good news however is that drugs for treating cancer aggravated by inflammation are already in the trials. So once the exact signals are found out, the work could be completed faster.
The research work was done using mice in which HPV was inserted. It a well known fact that HPV is tumourigenic virus causing cervical cancer. In the experiment, two batch of mice were created. One batch had the antibody receptors intact while the other mice were 'knock-out' of that receptor. The research showed that the former showed rapid growth of cancer cells while the other didn't show much progress.
2 comments:
Hello friends,
It was not always clear to scientists that the immune system played a role in preventing and combating cancer. Researchers and doctors in the late 1900s noticed, however that people with extremely weak or no immune system had a greater risk of developing cancer than the average person. In addition, researchers have since noticed that patients with immune cells present in their tumors have a better prognosis than patients without immune cells in their tumors. Thanks a lot!
Hello all,
I¡¯m seeking for buying a portable speaker to work with the iPhone 4 in order to "call" song birds. I want to utilize them as external speakers attached to a 10 to 15m cord so that I could keep the speakers close to the perch and operate the Phone of a hide.
Searched this information on the web many times and noticed the [url=http://www.potablespeakers.com]best portable speaker comparisons[/url] are objective. While I have a blank mind which one could meet my needs. What¡¯re your opinions about the best portable speakers you get?
Any ideas most welcome. Thanks guys.
Post a Comment